The self-powered piezoelectric sensor can effectively address the power supply issue for electronic skin. However, it remains challenging to fabricate flexible sensors with a modulus similar to that of human skin. This paper reports a PVDF-based organohydrogels as a piezoelectric senor for electronic skin. PVA serves a primary network, promoting the formation of the electroactive β phase in PVDF and ensuring the piezoelectric performance of the organohydrogel sensor. PA enhances crosslinking density and mechanical properties by forming hydrogen bonds with PVA, while also acting as a gelling agent to reduce PVA crystallization. Additionally, organic solvent DMSO is introduced to impart antifreeze properties to the sensor. The organohydrogel exhibits excellent anti-fatigue performance after 100 compression loading–unloading cycles. Additionally, the organohydrogel piezoelectric sensor demonstrates an impressive response time of approximately 8 ms and a wide pressure range of 0–30 N. Furthermore, the piezoelectric organohydrogel exhibits excellent anti-freezing properties, retaining its mechanical and piezoelectric characteristics even after being frozen at low temperature for 10 days. The PVDFbased organohydrogel has been proven to have significant potential for human motion detection without the need for an external power source.